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So looking at this, are we safe to assume that the Glp1 is the main
HO
Started by HopeMore
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20 replies
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9 people
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Last activity 11 Mar 2026, 14:14 UTC · Mar 11, 2026
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21 posts from 9 people ,
written between Jan 2026 and Mar 2026. Authors show as a member label or first name — they cannot reply here.
HO
HopeMore
163 posts · first seen Dec 2025
OP
So looking at this, are we safe to assume that the Glp1 is the main receptor of the three for modulating appetite?. I know its a complex drug and there would be more at play
HO
HopeMore
163 posts · first seen Dec 2025
I never tried the original sema, was it the most appetite suppresive of them all?
HO
HopeMore
163 posts · first seen Dec 2025
Im assuming thats why dosing started at 250mcg
HO
HopeMore
163 posts · first seen Dec 2025
Intreagued at what would be the most effective blend and looking at the chart, possibly a 75/25% reta/sema would be elite
AL
albert_8
5 posts · first seen Jan 2026
Probably because sema is a novo nordisk product.
GR
gridMyra
311 posts · first seen Sep 2025
Anyone else sleep fucked because of Reta?
PO
porch52
66 posts · first seen Dec 2025
Yea my sleep decreased from 8 to 6.5-7 hours
PO
porch52
66 posts · first seen Dec 2025
Wake up energetic though so i dont mind it
SH
shannon_hunte
434 posts · first seen Oct 2025
Easiest way to tell if Reta is impacting ur sleep is to track your RHR. If it goes up, the sleep issues are at least in part from Reta most likely
SH
shannon_hunte
434 posts · first seen Oct 2025
Gotcha. I have a Fitbit and my RHR def went up along side sleep issues when I started Reta
WW
wwilliams68
261 posts · first seen Oct 2025
Yeah quite normal
Didn’t sleep some nights on higher doses
GR
gridMyra
311 posts · first seen Sep 2025
Rhr in deep sleep is 32 after reta 42 so pretty high increase
GR
gridMyra
311 posts · first seen Sep 2025
I am also on anti depressants so idk which is causing insomnia trying to figure out which of the two is causing it so quitting reta for a while then
BR
brisk2
864 posts · first seen Dec 2025
YES. Everytime I re-pin it's impossible for me to fall asleep. I literally finally fell asleep at 7am this morning after thinking all night in bed
WW
wwilliams68
261 posts · first seen Oct 2025
Same situation with me and using adhd meds
Turns out it’s the Reta
BR
brisk2
864 posts · first seen Dec 2025
Are you more stimulated taking both ADHD and reta? I usually take Concerta
WW
wwilliams68
261 posts · first seen Oct 2025
Nah, wouldn’t say Reta stimulates me
Not enough anyway
BR
brisk2
864 posts · first seen Dec 2025
Are you on Concerta or vyvs? I really need to get back on meds but I would rather lose weight 😂 just worried I'll never sleep once I try stacking the two
CI
cinder_gar
29 posts · first seen Dec 2025
I never inject after 10am
BR
brook89
77 posts · first seen Nov 2025
Injection time never made a difference for me. It ruined my sleep 7 days a week
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