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There’s really no place for it besides the trash because they don’t do shit

Started by Jesse 29 replies 12 people Last activity Apr 24, 2026

Mar 20, 2026 #21
"Because me and my buddy Trev have been doing it this way for years with no problems" or something like that. 🤷
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Mar 22, 2026 #22
What do you think happened? Did you consider ph and buffer maybe? Antioxidant system?
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Mar 26, 2026 #23
no it all hapened 2 hours after I made it, I think I got it to too high of a concentration and after cooling down it crashed and crystalized. I heated it a bit to get it to dissolve, so I think once it went back to room temp the DMSO and the MCT oil split and it left an excessive amount of CoQ10 in the MCT oil (more than it is possible to dissolve in MCT oil alone) and it crashed. I tried to re-heat it to warm it up but nothing, remained a blob. I will try to re-make it using ethanol instead of DMSO and doing 50/50 ethanol and mct oil (instead of this 80/20 mct oil and dmso) and doing a lower concentration of 50mg/ml instead of 80mg/ml
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Mar 28, 2026 #24
From my experience making emulsions, sometimes you need to keep the solution moving/mixing til it cools. I think with heat, compounds will naturally separate out into their relative weights in layers until they lose heat. Reducing concentration is probably a good call too, I would assume oil solubility has limits like aqueous solutions.
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Apr 1, 2026 #25
I know it's not an emulsion but the concept still stands that they have different densities so you have to force the molecules to stay "in contact" by mixing until cool. Might not be the trick but would probably give you a better outcome next trial
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Apr 4, 2026 #26
I remade it with lower concentration of CoQ10, this time the coq10 remained dissolved in the mct oil without turning into a blob but the MCT oil and DMSO separated
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Apr 11, 2026 #27
oh might be right thakns. this time when I heated it the MCT and DMSO mixed, but after it cooled separated. maybe I try heating it again and keep the magnetic mixer on until it's fully cooled down?
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Apr 24, 2026 #28
Yeah that sounds like a solid approach. I was even thinking once you get the DMSO and MCT solution made first and cooled and stable, you should just be able to stir in the coq10 and it'll dissolve over time. Just a compromise that might just be the sacrifice in time required to make it work
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