Oh, that F U C K ALL I suppose
Fffffaaaark this bot
Running it with 500 test and 500 EQ
Hey guys, I’ve realised there might be a potential acne game changer many are missing out on and so I’ve decided to write up this very brief, minimally detailed guide.
Let’s get into it.
One of the more frustrating side effects of using androgens is cystic acne. While Accutane is available, it’s a fairly harsh option with systemic side effects.
I recently suggested (username redacted) a particular peptide as a means of overcoming his persistent acne and he has had amazing results.
The peptide is called LL-37 and I’ll briefly outline what it does, when it can be used, when it can’t be used, the dosing protocol I would explore if I were to use it, and where to buy it.
Note: none of this is medical advice, this is educational only and I would hope you’d research your own conditions before pinning this peptide.
What is LL-37 and what does it do?
LL-37 is an anti-microbial peptide which modulates the immune system, enhances the innate immune response, breaks down microbial cell membranes, stimulates tissue repair, and it has anti biofilm properties which is a big part of the issue with acne; this is where the bacteria forms a biofilm which protects it against your immune system and topicals, etc. If you prevent the development of these biofilms, you expose the bacteria to your immune system.
Skin Conditions Where LL-37 Can Make Things Better
Infections and wound healing can be improved by LL-37.
I would consider this if I had:
Acne
Impetigo
Folliculitis
Fungal infections
Viral skin infections
Post-acne scarring
Skin Conditions Where LL-37 Can Make Things Worse
Inflammatory and autoimmune conditions can be exacerbated by LL-37 as it enhances innate immunity which can trigger a stronger autoimmune response.
I would not use this if I had:
Rosacea
Psoriasis
Psoriatic arthritis
Rheumatoid arthritis
And more
Dosing
As a means of determining efficacy and tolerance, especially for those who might have a history of autoimmune skin conditions, it would be a good idea to start low and titrate up.
Note: This peptide is injected systemically, subcutaneously.
Here’s what that would look like for me:
Weeks 1-2
100mcg 2x per week
Monitor skin sensitivity, redness, flushing, or inflammatory flare-ups.
Weeks 3-4
200mcg 3x per week
Maintain this dose until week 8 if effective, else;
Weeks 5-8
300mcg 3x per week, or
200mcg EOD
Weeks 9-10
Break
Assess
Use weekly progress photos in the same lighting to track changes in lesion count, size, and scarring.
