Unfortunately there's quite a body of reports of people from vetted vendors on tested batches that see very little response on reta, especially compared to tirz and sema the suppression, for example, is quite marginal.
Given how reta is designed and operates (receptor affinity etc) it is also logical (and by design) that appetite is impacted quite a bit less than on its older brothers.
Note that I am not reflecting on its ability to promote weight loss.
What I personally really love and dislike about it is how it sends my metabolism in overdrive and disrupts my circadian rhythm, I just can't get a normal full night of sleep on it.
How long does it take to feel any appetite suppression or any effect from reta? I pinned 2mg a few days ago and 10mg 12 hours ago and have noticed nothing.